The Orbitrap Astral (Thermo Fisher Scientific) is a next-generation mass spectrometer combining three analyzers operating in parallel: an optimized quadrupole providing high ion transmission and rapid precursor selection, an Orbitrap offering resolution up to 480,000 with sub-1 ppm mass accuracy, and the Astral analyzer, based on a multi-reflection TOF technology enabling MS/MS acquisition rates of up to 200 Hz. This parallel architecture combines speed, sensitivity, and high resolution, with an analytical capacity of up to 180 samples per day and proteome coverage exceeding 12,000 proteins in one hour in human cells. The instrument also provides high sensitivity for single-cell proteomics, enabling the identification of several